{"id":17814,"date":"2024-12-17T23:56:14","date_gmt":"2024-12-17T22:56:14","guid":{"rendered":"https:\/\/biokteca.com\/grata-rerum-novitas-car-t-las-dos-caras-de-nuestro-sistema-inmunologico\/"},"modified":"2025-03-05T10:09:01","modified_gmt":"2025-03-05T09:09:01","slug":"grata-rerum-novitas-car-t-les-deux-facettes-de-notre-systeme-immunitaire","status":"publish","type":"post","link":"https:\/\/biokteca.com\/fr\/grata-rerum-novitas-car-t-les-deux-facettes-de-notre-systeme-immunitaire\/","title":{"rendered":"GRATA RERUM NOVITAS CAR-T : les deux facettes de notre syst\u00e8me immunitaire"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"17814\" class=\"elementor elementor-17814 elementor-16279\">\n\t\t\t\t<div class=\"elementor-element elementor-element-723530b e-flex e-con-boxed e-con e-parent\" data-id=\"723530b\" data-element_type=\"container\" data-settings=\"{&quot;wcf_enable_cursor_hover_effect_text&quot;:&quot;View&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1d8b387 elementor-widget elementor-widget-wcf--blog--post--title\" data-id=\"1d8b387\" data-element_type=\"widget\" data-settings=\"{&quot;wcf-animation&quot;:&quot;fade&quot;,&quot;data-duration&quot;:0.75,&quot;fade-offset&quot;:40,&quot;delay&quot;:0.15,&quot;fade-from&quot;:&quot;bottom&quot;,&quot;ease&quot;:&quot;power2.out&quot;}\" data-widget_type=\"wcf--blog--post--title.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"wcf--title\">GRATA RERUM NOVITAS CAR-T : les deux facettes de notre syst\u00e8me immunitaire<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d15deb7 e-con-full e-flex e-con e-child\" data-id=\"d15deb7\" data-element_type=\"container\" data-settings=\"{&quot;wcf_enable_cursor_hover_effect_text&quot;:&quot;View&quot;,&quot;wcf-animation&quot;:&quot;fade&quot;,&quot;data-duration&quot;:0.75,&quot;fade-offset&quot;:40,&quot;delay&quot;:0.15,&quot;fade-from&quot;:&quot;bottom&quot;,&quot;ease&quot;:&quot;power2.out&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-010a8b9 e-con-full e-flex e-con e-child\" data-id=\"010a8b9\" data-element_type=\"container\" data-settings=\"{&quot;wcf_enable_cursor_hover_effect_text&quot;:&quot;View&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ee37407 elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"ee37407\" data-element_type=\"widget\" data-settings=\"{&quot;wcf-animation&quot;:&quot;none&quot;}\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg 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fill=\"#8DCF9B\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b383f2b elementor-widget elementor-widget-wcf--blog--post--meta-info\" data-id=\"b383f2b\" data-element_type=\"widget\" data-settings=\"{&quot;wcf-animation&quot;:&quot;none&quot;}\" data-widget_type=\"wcf--blog--post--meta-info.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t        <ul class=\"wcf--meta-list style-2\">\r\n\t        \t\t\t\r\n\t\t\t                <li class=\"wcf--author-wrap\">\r\n                    <div class=\"wcf-author-img\">\r\n                        <img alt='' src='https:\/\/biokteca.com\/wp-content\/litespeed\/avatar\/3ae8c02fc2ca84c7a9f5515e949ce831.jpg?ver=1776177320' class='avatar avatar-55 photo' height='55' width='55' \/>                    <\/div>\r\n                    <div class=\"wcf--author-info\">\r\n                        <div class=\"wcf--author-title label\">\r\n\t\t                    R\u00e9dig\u00e9 par                        <\/div>\r\n                        <div class=\"wcf--meta-author\">\r\n                            <a href=\"https:\/\/biokteca.com\/fr\/author\/javier-raboso\/\">Javier Raboso<\/a>\r\n                        <\/div>\r\n                    <\/div>\r\n                <\/li>\r\n\t\t\t\t\t        <\/ul>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-28e028e e-con-full e-flex e-con e-child\" data-id=\"28e028e\" data-element_type=\"container\" data-settings=\"{&quot;wcf_enable_cursor_hover_effect_text&quot;:&quot;View&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f46d52d elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"f46d52d\" data-element_type=\"widget\" data-settings=\"{&quot;wcf-animation&quot;:&quot;none&quot;}\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"50\" height=\"50\" viewBox=\"0 0 50 50\" fill=\"none\"><rect opacity=\"0.1\" width=\"50\" height=\"50\" rx=\"25\" fill=\"#8DCF9B\"><\/rect><path d=\"M30.8333 16.6667H30V15.8333C30 15.3733 29.6275 15 29.1667 15C28.7058 15 28.3333 15.3733 28.3333 15.8333V16.6667H21.6667V15.8333C21.6667 15.3733 21.2942 15 20.8333 15C20.3725 15 20 15.3733 20 15.8333V16.6667H19.1667C16.8692 16.6667 15 18.5358 15 20.8333V30.8333C15 33.1308 16.8692 35 19.1667 35H30.8333C33.1308 35 35 33.1308 35 30.8333V20.8333C35 18.5358 33.1308 16.6667 30.8333 16.6667ZM19.1667 18.3333H30.8333C32.2117 18.3333 33.3333 19.455 33.3333 20.8333V21.6667H16.6667V20.8333C16.6667 19.455 17.7883 18.3333 19.1667 18.3333ZM30.8333 33.3333H19.1667C17.7883 33.3333 16.6667 32.2117 16.6667 30.8333V23.3333H33.3333V30.8333C33.3333 32.2117 32.2117 33.3333 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    <div class=\"wcf--category-title label\">\r\n\t\t                    \t\t                    Cat\u00e9gorie                        <\/div>\r\n                        <ul class=\"wcf--category-list\">\r\n\t\t\t\t\t\t\t                                <li class=\"wcf--meta-category wcf-separator\"\r\n                                    data-separator=\"|\">\r\n                                    <a class=\"wcf-btn-default btn-hover-none\" href=\"https:\/\/biokteca.com\/fr\/category\/actualites\/\">\r\n\t\t\t\t\t\t\t\t\t\tActualit\u00e9s                                    <\/a>\r\n                                <\/li>\r\n\t\t\t\t\t\t\t                            <\/ul>\r\n                    <\/li>\r\n\t\t\t\t\t\t\t\t\t        <\/ul>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fb55d39 e-con-full e-flex e-con e-child\" data-id=\"fb55d39\" data-element_type=\"container\" 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35C25.1948 35 25.3855 34.9301 25.536 34.8028L29.2502 31.6669H31.6669C32.551 31.6669 33.3988 31.3157 34.024 30.6906C34.6491 30.0654 35.0003 29.2176 35.0003 28.3335V18.3334C35.0003 17.4493 34.6491 16.6015 34.024 15.9763C33.3988 15.3512 32.551 15 31.6669 15ZM33.3336 28.3335C33.3336 28.7756 33.158 29.1995 32.8454 29.512C32.5329 29.8246 32.1089 30.0002 31.6669 30.0002H29.2502C28.8563 30.0003 28.4751 30.14 28.1744 30.3944L25.0001 33.0753L21.8276 30.3944C21.5264 30.1396 21.1446 29.9999 20.7501 30.0002H18.3334C17.8913 30.0002 17.4674 29.8246 17.1549 29.512C16.8423 29.1995 16.6667 28.7756 16.6667 28.3335V18.3334C16.6667 17.8913 16.8423 17.4674 17.1549 17.1549C17.4674 16.8423 17.8913 16.6667 18.3334 16.6667H31.6669C32.1089 16.6667 32.5329 16.8423 32.8454 17.1549C33.158 17.4674 33.3336 17.8913 33.3336 18.3334V28.3335Z\" fill=\"#8DCF9B\"><\/path><path d=\"M20.8334 20.8334H25.0001C25.2212 20.8334 25.4331 20.7456 25.5894 20.5893C25.7457 20.4331 25.8335 20.2211 25.8335 20.0001C25.8335 19.7791 25.7457 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                    <span>minutes read<\/span>\r\n                    <\/div>\r\n                <\/li>\r\n\t\t\t\t\t        <\/ul>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c00716d elementor-widget elementor-widget-wcf--image\" data-id=\"c00716d\" data-element_type=\"widget\" data-settings=\"{&quot;wcf-animation&quot;:&quot;fade&quot;,&quot;wcf-image-animation&quot;:&quot;none&quot;,&quot;delay&quot;:0.15,&quot;fade-from&quot;:&quot;bottom&quot;,&quot;data-duration&quot;:1.5,&quot;ease&quot;:&quot;power2.out&quot;,&quot;fade-offset&quot;:50}\" data-widget_type=\"wcf--image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"wcf--image\">\r\n\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1290\" height=\"720\" src=\"https:\/\/biokteca.com\/wp-content\/uploads\/2024\/12\/blog-grata-rerum-ok-int.webp\" class=\"attachment-full size-full wp-image-16781\" alt=\"\" srcset=\"https:\/\/biokteca.com\/wp-content\/uploads\/2024\/12\/blog-grata-rerum-ok-int.webp 1290w, https:\/\/biokteca.com\/wp-content\/uploads\/2024\/12\/blog-grata-rerum-ok-int-300x167.webp 300w, https:\/\/biokteca.com\/wp-content\/uploads\/2024\/12\/blog-grata-rerum-ok-int-1024x572.webp 1024w, https:\/\/biokteca.com\/wp-content\/uploads\/2024\/12\/blog-grata-rerum-ok-int-768x429.webp 768w\" sizes=\"(max-width: 1290px) 100vw, 1290px\" \/>\t\t<\/div>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c501e11 e-flex e-con-boxed e-con e-parent\" data-id=\"c501e11\" data-element_type=\"container\" data-settings=\"{&quot;wcf_enable_cursor_hover_effect_text&quot;:&quot;View&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7c47826 e-con-full animated-slow e-flex elementor-invisible e-con e-child\" data-id=\"7c47826\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;,&quot;wcf_enable_cursor_hover_effect_text&quot;:&quot;View&quot;,&quot;data-duration&quot;:0.75,&quot;wcf-animation&quot;:&quot;fade&quot;,&quot;fade-offset&quot;:40,&quot;delay&quot;:0.15,&quot;on-scroll&quot;:1,&quot;fade-from&quot;:&quot;bottom&quot;,&quot;ease&quot;:&quot;power2.out&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-cb8aec0 e-con-full e-flex e-con e-child\" data-id=\"cb8aec0\" data-element_type=\"container\" data-settings=\"{&quot;wcf_enable_cursor_hover_effect_text&quot;:&quot;View&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-81e50ef elementor-view-default elementor-position-top elementor-mobile-position-top elementor-widget elementor-widget-icon-box\" data-id=\"81e50ef\" data-element_type=\"widget\" data-settings=\"{&quot;wcf-animation&quot;:&quot;none&quot;}\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon elementor-animation-\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"17\" height=\"19\" viewBox=\"0 0 17 19\" fill=\"none\"><path id=\"Vector\" d=\"M13.5353 11.8304C12.4643 11.8304 11.5055 12.3358 10.8693 13.128L6.73098 10.6975C6.85967 10.3229 6.93041 9.92007 6.93041 9.50029C6.93041 9.0806 6.85967 8.67779 6.73098 8.30317L10.869 5.87205C11.5051 6.66453 12.464 7.1701 13.5351 7.1701C15.4456 7.1701 16.9999 5.56165 16.9999 3.58451C17.0001 1.60795 15.4458 0 13.5353 0C11.6246 0 10.0701 1.60795 10.0701 3.58442C10.0701 4.0042 10.1407 4.40709 10.2695 4.7818L6.13126 7.213C5.49516 6.42094 4.53644 5.9157 3.46569 5.9157C1.55472 5.9157 0 7.52365 0 9.50021C0 11.4767 1.55472 13.0846 3.46569 13.0846C4.53644 13.0846 5.49508 12.5794 6.13118 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                  <a href=\"https:\/\/biokteca.com\/fr\/grata-rerum-novitas-car-t-les-deux-facettes-de-notre-systeme-immunitaire\/\"\r\n                       data-social=\"facebook\">\r\n                        <span class=\"wcf-social-icn \"><i aria-hidden=\"true\" class=\"share-ico binox-theme wcftheme-wcf-icon icon-wcf-facebook\"><\/i><\/span>\r\n                        <span class=\"info-s-title\"> Facebook <\/span>\r\n\t\t\t\t\t\t                            <span>\r\n                                                                                            <\/span>\r\n\t\t\t\t\t\t                    <\/a>\r\n                <\/li>\r\n\t\t\t                <li>\r\n                    <a href=\"https:\/\/biokteca.com\/fr\/grata-rerum-novitas-car-t-les-deux-facettes-de-notre-systeme-immunitaire\/\"\r\n                       data-social=\"twitter\">\r\n                        <span class=\"wcf-social-icn \"><svg aria-hidden=\"true\" class=\"share-ico e-font-icon-svg 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class=\"info-s-title\"> Linkedin <\/span>\r\n\t\t\t\t\t\t                            <span>\r\n                                                                                            <\/span>\r\n\t\t\t\t\t\t                    <\/a>\r\n                <\/li>\r\n\t\t\t        <\/ul>\r\n\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c4d9b4b e-con-full e-flex e-con e-child\" data-id=\"c4d9b4b\" data-element_type=\"container\" data-settings=\"{&quot;wcf_enable_cursor_hover_effect_text&quot;:&quot;View&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-7d9a514 e-con-full e-flex e-con e-child\" data-id=\"7d9a514\" data-element_type=\"container\" data-settings=\"{&quot;wcf_enable_cursor_hover_effect_text&quot;:&quot;View&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-4abd5fe e-con-full e-flex e-con e-child\" data-id=\"4abd5fe\" data-element_type=\"container\" data-settings=\"{&quot;wcf_enable_cursor_hover_effect_text&quot;:&quot;View&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-00b53a6 e-flex e-con-boxed e-con e-child\" data-id=\"00b53a6\" data-element_type=\"container\" data-settings=\"{&quot;wcf_enable_cursor_hover_effect_text&quot;:&quot;View&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c4828d1 elementor-widget-mobile_extra__width-inherit wcf-t-animation-none elementor-widget elementor-widget-text-editor\" data-id=\"c4828d1\" data-element_type=\"widget\" data-settings=\"{&quot;on-scroll&quot;:&quot;1&quot;,&quot;data-duration&quot;:0.75,&quot;wcf-animation&quot;:&quot;fade&quot;,&quot;fade-offset&quot;:40,&quot;wcf_text_animation&quot;:&quot;none&quot;,&quot;delay&quot;:0.15,&quot;fade-from&quot;:&quot;bottom&quot;,&quot;ease&quot;:&quot;power2.out&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Les cellules CAR-T sont un type de traitement dans lequel les cellules T d&rsquo;un patient (un type de cellule immunitaire) sont modifi\u00e9es en laboratoire pour qu&rsquo;elles se lient aux cellules canc\u00e9reuses et les d\u00e9truisent. Le sang d&rsquo;une veine du bras du patient s&rsquo;\u00e9coule dans un tube jusqu&rsquo;\u00e0 une machine d&rsquo;aph\u00e9r\u00e8se, qui extrait les globules blancs, y compris les cellules T, et renvoie le reste du sang au patient. Ensuite, le g\u00e8ne d&rsquo;un r\u00e9cepteur sp\u00e9cial appel\u00e9 r\u00e9cepteur d&rsquo;antig\u00e8ne chim\u00e9rique (CAR) est ins\u00e9r\u00e9 dans les cellules T en laboratoire. Des millions de cellules CAR-T sont cultiv\u00e9es en laboratoire, puis administr\u00e9es au patient par perfusion. Les cellules CAR-T peuvent se lier \u00e0 un antig\u00e8ne des cellules canc\u00e9reuses et les tuer (<strong>Figure 1<\/strong>).<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ee94bfa elementor-widget elementor-widget-wcf--image\" data-id=\"ee94bfa\" data-element_type=\"widget\" data-settings=\"{&quot;wcf-image-animation&quot;:&quot;none&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\" data-widget_type=\"wcf--image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"wcf--image\">\r\n\t\t\t<img decoding=\"async\" width=\"1290\" height=\"720\" src=\"https:\/\/biokteca.com\/wp-content\/uploads\/2024\/12\/car-t-sistema-inmunologico-1.webp\" class=\"attachment-full size-full wp-image-16290\" alt=\"\" srcset=\"https:\/\/biokteca.com\/wp-content\/uploads\/2024\/12\/car-t-sistema-inmunologico-1.webp 1290w, https:\/\/biokteca.com\/wp-content\/uploads\/2024\/12\/car-t-sistema-inmunologico-1-300x167.webp 300w, https:\/\/biokteca.com\/wp-content\/uploads\/2024\/12\/car-t-sistema-inmunologico-1-1024x572.webp 1024w, https:\/\/biokteca.com\/wp-content\/uploads\/2024\/12\/car-t-sistema-inmunologico-1-768x429.webp 768w\" sizes=\"(max-width: 1290px) 100vw, 1290px\" \/>\t\t<\/div>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b95678b wcf-t-animation-none elementor-widget elementor-widget-text-editor\" data-id=\"b95678b\" data-element_type=\"widget\" data-settings=\"{&quot;on-scroll&quot;:&quot;1&quot;,&quot;data-duration&quot;:0.75,&quot;wcf-animation&quot;:&quot;fade&quot;,&quot;fade-offset&quot;:40,&quot;wcf_text_animation&quot;:&quot;none&quot;,&quot;delay&quot;:0.15,&quot;fade-from&quot;:&quot;bottom&quot;,&quot;ease&quot;:&quot;power2.out&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p style=\"text-align: center;\"><strong>Figure 1. <\/strong>Sch\u00e9ma repr\u00e9sentatif de la g\u00e9n\u00e9ration de cellules CAR-T.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-33ef4cf elementor-widget-laptop__width-initial wcf-t-animation-none elementor-widget elementor-widget-text-editor\" data-id=\"33ef4cf\" data-element_type=\"widget\" data-settings=\"{&quot;on-scroll&quot;:&quot;1&quot;,&quot;data-duration&quot;:0.75,&quot;wcf-animation&quot;:&quot;fade&quot;,&quot;fade-offset&quot;:40,&quot;wcf_text_animation&quot;:&quot;none&quot;,&quot;delay&quot;:0.15,&quot;fade-from&quot;:&quot;bottom&quot;,&quot;ease&quot;:&quot;power2.out&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>La th\u00e9rapie par cellules T \u00e0 r\u00e9cepteur antig\u00e9nique chim\u00e9rique (CAR-T) a \u00e9t\u00e9 r\u00e9volutionnaire car elle a produit des r\u00e9ponses cliniques remarquablement efficaces et durables. Les CAR sont des r\u00e9cepteurs synth\u00e9tiques con\u00e7us pour rediriger les lymphocytes ou les cellules T afin qu&rsquo;ils reconnaissent et \u00e9liminent les cellules exprimant un antig\u00e8ne cible sp\u00e9cifique. La liaison des CAR aux antig\u00e8nes cibles exprim\u00e9s \u00e0 la surface cellulaire est ind\u00e9pendante du r\u00e9cepteur MHC, ce qui entra\u00eene une forte activation des cellules T et de puissantes r\u00e9ponses antitumorales.<\/p><p>Le succ\u00e8s sans pr\u00e9c\u00e9dent de la th\u00e9rapie par cellules CAR-T anti-CD19 contre les n\u00e9oplasies malignes \u00e0 cellules B a conduit \u00e0 l&rsquo;approbation de 6 m\u00e9dicaments au total par l&rsquo;Agence europ\u00e9enne des m\u00e9dicaments (EMA) (<strong>Tableau 1<\/strong>).<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76e8860 elementor-widget elementor-widget-wcf--image\" data-id=\"76e8860\" data-element_type=\"widget\" data-settings=\"{&quot;wcf-image-animation&quot;:&quot;none&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\" data-widget_type=\"wcf--image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"wcf--image\">\r\n\t\t\t<img decoding=\"async\" width=\"768\" height=\"1008\" src=\"https:\/\/biokteca.com\/wp-content\/uploads\/2024\/12\/Captura-de-pantalla-2025-03-05-a-las-9.50.13-1-768x1008.png\" class=\"attachment-medium_large size-medium_large wp-image-18204\" alt=\"\" srcset=\"https:\/\/biokteca.com\/wp-content\/uploads\/2024\/12\/Captura-de-pantalla-2025-03-05-a-las-9.50.13-1-768x1008.png 768w, https:\/\/biokteca.com\/wp-content\/uploads\/2024\/12\/Captura-de-pantalla-2025-03-05-a-las-9.50.13-1-229x300.png 229w, https:\/\/biokteca.com\/wp-content\/uploads\/2024\/12\/Captura-de-pantalla-2025-03-05-a-las-9.50.13-1-780x1024.png 780w, https:\/\/biokteca.com\/wp-content\/uploads\/2024\/12\/Captura-de-pantalla-2025-03-05-a-las-9.50.13-1.png 826w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t<\/div>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6860a50 wcf-t-animation-none elementor-widget elementor-widget-text-editor\" data-id=\"6860a50\" data-element_type=\"widget\" data-settings=\"{&quot;on-scroll&quot;:&quot;1&quot;,&quot;data-duration&quot;:0.75,&quot;wcf-animation&quot;:&quot;fade&quot;,&quot;fade-offset&quot;:40,&quot;wcf_text_animation&quot;:&quot;none&quot;,&quot;delay&quot;:0.15,&quot;fade-from&quot;:&quot;bottom&quot;,&quot;ease&quot;:&quot;power2.out&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p style=\"text-align: center;\"><strong>Tableau 1. <\/strong>Th\u00e9rapies CAR-T actuellement approuv\u00e9es par l&rsquo;EMA.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db0e69c wcf-t-animation-none elementor-widget elementor-widget-text-editor\" data-id=\"db0e69c\" data-element_type=\"widget\" data-settings=\"{&quot;on-scroll&quot;:&quot;1&quot;,&quot;data-duration&quot;:0.75,&quot;wcf-animation&quot;:&quot;fade&quot;,&quot;fade-offset&quot;:40,&quot;wcf_text_animation&quot;:&quot;none&quot;,&quot;delay&quot;:0.15,&quot;fade-from&quot;:&quot;bottom&quot;,&quot;ease&quot;:&quot;power2.out&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Cependant, il existe d&rsquo;importantes limites \u00e0 la th\u00e9rapie par cellules CAR-T qui doivent encore \u00eatre abord\u00e9es, notamment les toxicit\u00e9s associ\u00e9es aux cellules CAR-T qui mettent la vie en danger, l&rsquo;efficacit\u00e9 limit\u00e9e contre les tumeurs solides, l&rsquo;inhibition et la r\u00e9sistance dans les n\u00e9oplasies malignes des cellules B, l&rsquo;\u00e9chappement aux antig\u00e8nes, la persistance limit\u00e9e, le mauvais trafic et l&rsquo;infiltration tumorale, et la micro-environnement immunosuppresseur. En outre, la main-d&rsquo;\u0153uvre doit s&rsquo;adapter pour r\u00e9pondre aux besoins de ce domaine en pleine croissance et \u00e9volution en d\u00e9veloppant des programmes \u00e9ducatifs pour la former.<\/p><p>De nombreuses approches ont \u00e9t\u00e9 propos\u00e9es, notamment la combinaison de la th\u00e9rapie CAR-T avec d&rsquo;autres th\u00e9rapies anticanc\u00e9reuses ou l&rsquo;utilisation de strat\u00e9gies innovantes d&rsquo;ing\u00e9nierie CAR pour am\u00e9liorer l&rsquo;efficacit\u00e9 antitumorale, \u00e9tendre l&rsquo;efficacit\u00e9 clinique et limiter les toxicit\u00e9s. En ce qui concerne leurs effets secondaires potentiels, les plus courants sont la diarrh\u00e9e, les vomissements, les c\u00e9phal\u00e9es, les \u00e9tourdissements et la faiblesse. Plus graves sont la neurotoxicit\u00e9 ou le tr\u00e8s connu \u00ab cytokine storm \u00bb, tous deux r\u00e9sultant du fonctionnement de ce type de th\u00e9rapie g\u00e9nique qui d\u00e9clenche un processus inflammatoire syst\u00e9mique en cascade.<\/p><p>\u00c0 cet \u00e9gard, il ne faut pas oublier qu&rsquo;\u00e0 la fin de l&rsquo;ann\u00e9e 2023, la FDA a \u00e9mis un avertissement de \u00ab risque grave \u00bb apr\u00e8s avoir re\u00e7u 19 rapports de malignit\u00e9 des cellules T chez des patients trait\u00e9s. Cela affecterait les 6 th\u00e9rapies bas\u00e9es sur les CAR-T approuv\u00e9es \u00e0 ce jour (<strong>Tableau 1<\/strong>), mais les sp\u00e9cialistes avertissent qu&rsquo;il s&rsquo;agit d&rsquo;une proc\u00e9dure de s\u00e9curit\u00e9 habituelle et que les avantages l&#8217;emportent largement sur les probl\u00e8mes potentiels. N\u00e9anmoins, au niveau national, nous disposons de chercheurs et d&rsquo;\u00e9quipes de professionnels qui cherchent d\u00e9j\u00e0 \u00e0 aller plus loin que la technique. Leur objectif : renforcer la polyvalence et les avantages des cellules CAR-T, tout en minimisant leurs limites.<\/p><p>Un exemple en est l&rsquo;ambitieux projet men\u00e9 par des chercheurs du Centre sup\u00e9rieur de recherches scientifiques (CSIC) qui d\u00e9veloppera des capsules biologiques contenant des cellules CAR-T (cellules immunitaires con\u00e7ues sp\u00e9cifiquement pour attaquer des mol\u00e9cules exprim\u00e9es dans certains sous-types de tumeurs) pour traiter plus efficacement et plus sp\u00e9cifiquement les tumeurs solides. Comme un cheval de Troie microscopique, ces capsules ou pilules minuscules dissimuleront des cellules antitumorales \u00e0 l&rsquo;int\u00e9rieur et pourront ainsi envahir la zone canc\u00e9reuse et \u00e9liminer les cellules malignes de l&rsquo;int\u00e9rieur de la tumeur. Le projet, financ\u00e9 par le minist\u00e8re des Sciences et de l&rsquo;Innovation, implique le Centre de recherche sur le cancer de Salamanque (CIC, un institut de recherche mixte du CSIC et de l&rsquo;Universit\u00e9 de Salamanque), le Centre de recherche biom\u00e9dicale en r\u00e9seau sur le cancer (CIBERONC), l&rsquo;Universit\u00e9 de Saint-Jacques-de-Compostelle (USC) et le Centre de recherche en m\u00e9decine appliqu\u00e9e (CIMA) de l&rsquo;Universit\u00e9 de Navarre.<\/p><p>Un autre exemple clair est celui des chercheurs du groupe d&rsquo;h\u00e9matologie exp\u00e9rimentale de l&rsquo;Institut d&rsquo;oncologie Vall d&rsquo;Hebron (VHIO), qui fait partie du campus Vall d&rsquo;Hebron. Ils ont particip\u00e9 au d\u00e9veloppement d&rsquo;une nouvelle technologie permettant de traiter les cellules CAR-T plus rapidement et plus efficacement, ce qui pourrait r\u00e9duire le temps d&rsquo;attente des patients avant de recevoir le traitement. Les r\u00e9sultats de l&rsquo;\u00e9tude sur des mod\u00e8les pr\u00e9cliniques et les r\u00e9sultats pr\u00e9liminaires du premier essai clinique sur des patients atteints de lymphome non hodgkinien B ont \u00e9t\u00e9 publi\u00e9s dans la revue <em>Cancer Discovery<\/em>.<\/p><p>Cela d\u00e9montre la position de l&rsquo;Espagne comme l&rsquo;un des \u00e9l\u00e9ments cl\u00e9s dans la mise au point et l&rsquo;optimisation de l&rsquo;une des th\u00e9rapies les plus r\u00e9volutionnaires sur le plan technologique de ces derni\u00e8res ann\u00e9es.<\/p><p>En ce qui concerne la r\u00e9glementation et les normes applicables, les CAR-T sont un type de m\u00e9dicament biologique humain et plus pr\u00e9cis\u00e9ment un type de th\u00e9rapie avanc\u00e9e, auquel s&rsquo;applique donc la partie IV des normes de bonne fabrication (BPF). De m\u00eame, comme indiqu\u00e9 dans le guide <em>EMA\/CAT\/600280\/2010 Rev.1<\/em> :<\/p><p><em>\u2018Gene therapy medicinal product means a biological medicinal product which fulfils the following two characteristics:<\/em><\/p><p><em>(a) it contains an active substance which contains or consists of a recombinant nucleic acid used in or administered to human beings with a view to regulating, repairing, replacing, adding or deleting a genetic sequence.<\/em><\/p><p><em>(b) its therapeutic, prophylactic or diagnostic effect relates directly to the recombinant nucleic acid sequence it contains, or to the product of genetic expression of this sequence.<\/em><\/p><p><em>Gene therapy medicinal products shall not include vaccines against infectious diseases.\u2019<\/em><\/p><p>Les cellules CAR-T \u00e9tant des cellules T g\u00e9n\u00e9tiquement modifi\u00e9es, elles sont donc consid\u00e9r\u00e9es comme un produit de th\u00e9rapie g\u00e9nique.<\/p><p>\u00a0<\/p><p><strong>Bibliographie<\/strong>:<\/p><ol><li>De Marco R. C., Monzo H. J., Ojala P. M. CAR T Cell Therapy: A Versatile Living Drug.<em>IJMS<\/em>,\u00a02023; <em>24<\/em>(7), 6300. <a href=\"https:\/\/doi.org\/10.3390\/ijms24076300\">https:\/\/doi.org\/10.3390\/ijms24076300<\/a>.<\/li><li>Labanieh L., Majzner R.G., Mackall C.L. Programming CAR-T Cells to Kill Cancer.<em> Biomed. Eng.<\/em><em>\u00a0<\/em>2018;2:377\u2013391. doi:\u00a010.1038\/s41551-018-0235-9.\u00a0<\/li><li>Sterner R.C., Sterner R.M. CAR-T Cell Therapy: Current Limitations and Potential Strategies.\u00a0<em>Blood Cancer J.\u00a0<\/em>2021;11:69. doi:\u00a010.1038\/s41408-021-00459-7.<\/li><li>Wagner D.L., Fritsche E., Pulsipher M.A., Ahmed N., Hamieh M., Hegde M., Ruella M., Savoldo B., Shah N.N., Turtle C.J., et al. Immunogenicity of CAR T Cells in Cancer Therapy.<em> Rev. Clin. Oncol.<\/em><em>\u00a0<\/em>2021;18:379\u2013393. doi:\u00a010.1038\/s41571-021-00476-2.\u00a0<\/li><li>Park J.H., Rivi\u00e8re I., Gonen M., Wang X., S\u00e9n\u00e9chal B, Curran K.J., et al. Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia. <em>N Engl J Med<\/em>. 2018;378:449\u201359. doi: <a href=\"https:\/\/doi.org\/10.1056\/nejmoa1709919\">1056\/NEJMoa1709919<\/a>.<\/li><\/ol>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-04dc47d elementor-widget elementor-widget-wcf--blog--post--tags\" data-id=\"04dc47d\" data-element_type=\"widget\" data-settings=\"{&quot;on-scroll&quot;:&quot;1&quot;,&quot;data-duration&quot;:0.75,&quot;wcf-animation&quot;:&quot;fade&quot;,&quot;fade-offset&quot;:40,&quot;delay&quot;:0.15,&quot;fade-from&quot;:&quot;bottom&quot;,&quot;ease&quot;:&quot;power2.out&quot;}\" data-widget_type=\"wcf--blog--post--tags.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t        <div class=\"wcf--post-tags\">\r\n\t\t\t        <\/div>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a11fdeb e-con-full e-flex e-con e-child\" data-id=\"a11fdeb\" data-element_type=\"container\" data-settings=\"{&quot;wcf_enable_cursor_hover_effect_text&quot;:&quot;View&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Les cellules CAR-T sont un type de traitement dans lequel les cellules T d\u2019un patient (un type de cellule immunitaire) sont modifi\u00e9es en laboratoire pour se lier aux cellules canc\u00e9reuses et les d\u00e9truire.<\/p>\n","protected":false},"author":3,"featured_media":17758,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-17814","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites"],"_links":{"self":[{"href":"https:\/\/biokteca.com\/fr\/wp-json\/wp\/v2\/posts\/17814","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biokteca.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biokteca.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biokteca.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biokteca.com\/fr\/wp-json\/wp\/v2\/comments?post=17814"}],"version-history":[{"count":5,"href":"https:\/\/biokteca.com\/fr\/wp-json\/wp\/v2\/posts\/17814\/revisions"}],"predecessor-version":[{"id":18212,"href":"https:\/\/biokteca.com\/fr\/wp-json\/wp\/v2\/posts\/17814\/revisions\/18212"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biokteca.com\/fr\/wp-json\/wp\/v2\/media\/17758"}],"wp:attachment":[{"href":"https:\/\/biokteca.com\/fr\/wp-json\/wp\/v2\/media?parent=17814"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biokteca.com\/fr\/wp-json\/wp\/v2\/categories?post=17814"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biokteca.com\/fr\/wp-json\/wp\/v2\/tags?post=17814"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}